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CBL1348 Anti-Integrin beta1 Antibody, clone HM beta 1.1

Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: CD29, FNRB, GPIIA , MDF2 , MSK12 , OTTHUMP00000019420 , OTTHUMP00000046253, OTTHUMP00000063731, OTTHUMP00000063732, OTTHUMP00000063733, VLA-BETA, VLAB UniProt Number: P09055
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CBL1348
100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICCHtPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL1348
      DescriptionAnti-Integrin beta1 Antibody, clone HM beta 1.1
      Alternate Names
      • CD29 antigen
      • Fibronectin receptor subunit beta
      • Integrin VLA-4 subunit beta
      • fibronectin receptor beta subunit
      • integrin VLA-4 beta subunit
      • integrin beta 1
      • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen
        CD29 includes MDF2, MSK12)
      Background InformationIntegrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Control
      • NIH3T3, A431
      PresentationPurified in PBS with 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationDetect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenPurified mouse VLA-4 antigen
      EpitopeFull length
      CloneHM beta 1.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostHamster
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteReacts with mouse and human. Other species have not been tested.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryIntegrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq]
      Gene Symbol
      • CD29
      • FNRB
      • GPIIA
      • MDF2
      • MSK12
      • OTTHUMP00000019420
      • OTTHUMP00000046253
      • OTTHUMP00000063731
      • OTTHUMP00000063732
      • OTTHUMP00000063733
      • VLA-BETA
      • VLAB
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA, FLNB, FLNC and RANBP9. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity).
      LOCATION: Membrane; Single-pass type I membrane protein. Melanosome (By similarity).
      SIMILARITY: Belongs to the integrin beta chain family.
      SIMILARITY: Contains 1 VWFA domain.
      Molecular Weight130 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      CBL1348 04053252516559

      Documentation

      Anti-Integrin beta1 Antibody, clone HM beta 1.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin beta1 Antibody, clone HM beta 1.1 Certificates of Analysis

      TitleLot Number
      Anti-Integrin beta1, clone HM beta 1.1 - 2424779 2424779
      Anti-Integrin beta1, clone HM beta 1.1 - 2011462 2011462
      Anti-Integrin beta1, clone HM beta 1.1 - 2109564 2109564
      Anti-Integrin beta1, clone HM beta 1.1 - 2300032 2300032
      Anti-Integrin beta1, clone HM beta 1.1 - 3176037 3176037
      Anti-Integrin beta1, clone HM beta 1.1 - 3259522 3259522
      Anti-Integrin beta1, clone HM beta 1.1 - 3380295 3380295
      Anti-Integrin beta1, clone HM beta 1.1 - LV1758406 LV1758406
      Anti-Integrin beta1, clone HM beta 1.1 - NG1554550 NG1554550
      Anti-Integrin beta1, clone HM beta 1.1 - NG1873185 NG1873185
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