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MABC1105-100UG Anti-MORC3 Antibody, clone 17A9

Anti-MORC3, clone 17A9, Cat. No. MABC1105, is a mouse monoclonal antibody that detects MORC family CW-type zinc finger protein 3 and is tested for use in Immunocytochemistry and Western Blotting.

MABC1105-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABC1105-100UG
      DescriptionAnti-MORC3 Antibody, clone 17A9
      Alternate Names
      • MORC family CW-type zinc finger protein 3
      • Nuclear matrix protein 2
      • Zinc finger CW-type coiled-coil domain protein 3
      Background InformationMORC family CW-type zinc finger protein 3 (UniProt: Q14149; also known as Nuclear matrix protein 2, Zinc finger CW-type coiled-coil domain protein 3) is encoded by the MORC3 (also known as KIAA0136, NXP2, ZCWCC3) gene (Gene ID: 23515) in human. MORC3 is a homodimeric protein of the MORC protein family characterized by conserved structures consisting of Gyrase H, Hsp90, and MutL (GHL)-ATPase domain at its N-terminus and a CW type zinc finger domain (aa 404-454). It is expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, and liver. MORC3 serves as a nuclear factor that forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. It is also shown to be a target of herpes simplelx virus 1 (HSV-1) ICP0-mediated degradation. It is shown to be essential for fully efficient recruitment of PML, Sp100, hDaxx, and H2AX to sites associated with HSV-1 genomes entering the host cell nucleus. MORC3 recruits TP53 and SP100 to PML-NBs, hence, it is also involved in the regulation of TP53 activity. It regulates p53 activation via MORC3-ATPase activity. It can also induce p53-dependent premature senescence. (Ref.: Takahashi, K., et al. (2007). Mol Biol Cell. 18(5): 1701 1709; Sloan, E., et al. (2016). J. virology. 90(19); 8621-8633).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-MORC3, clone 17A9, Cat. No. MABC1105, is a mouse monoclonal antibody that detects MORC family CW-type zinc finger protein 3 and is tested for use in Immunocytochemistry and Western Blotting.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A representative lot detected MORC3 in Immunocytochemistry applications (Takahashi, K., et. al. (2007). Mol Biol Cell. 18(5):1701-9).

      Western Blotting Analysis: A 1:250 dilution from a representative lot detected MORC3 in PC12 cell lysates.
      Biological Information
      ImmunogenHis-tagged full-length recombinant human MORC family CW-type zinc finger protein 3 (MORC3).
      Clone17A9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 17A9 is a mouse monoclonal antibody that specifically detects MORC family CW-type zinc finger protein 3 (MORC3). It targets an epitope with the C-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MORC3
      • KIAA0136
      • NXP2
      • ZCWCC3
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~ 160 and 230 kDa observed; 107.11 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in NIH/3T3 cell lysates.

      Western Blotting Analysis: 1 µg/mL of this antibody detected MORC3 in NIH/3T3 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABC1105-100UG 04054839986741

      Documentation

      Anti-MORC3 Antibody, clone 17A9 Certificates of Analysis

      TitleLot Number
      Anti-MORC3, clone 17A9 - Q3222082 Q3222082

      References

      Reference overviewPub Med ID
      Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
      Takahashi, K; Yoshida, N; Murakami, N; Kawata, K; Ishizaki, H; Tanaka-Okamoto, M; Miyoshi, J; Zinn, AR; Shime, H; Inoue, N
      Mol Biol Cell  18  1701-9  2007

      Show Abstract Full Text Article      		17332504 17332504