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AB10439 Anti-PACSIN1 Antibody, NT

Anti-PACSIN1 Antibody, N-terminus detects level of PACSIN1 & has been published & validated for use in WB, IH(P).

Anti-PACSIN1 Antibody, NT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeletal Signaling Gene Symbol: KIAA1379, OTTHUMP00000016231, SDPI UniProt Number: Q9BY11
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AB10439
100 µg   
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10439
      DescriptionAnti-PACSIN1 Antibody, NT
      Alternate Names
      • protein kinase C and casein kinase substrate in neurons 1
      • syndapin I
      Background InformationPACSINs, also known as syndapins, are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN1 has been implicated as playing a central role in synaptic vesicle recycling (Kessels, 2004). Expected molecular weight is 51 kDa.
      References
      Product Information
      FormatPurified
      Control
      • Mouse brain lysate
      PresentationPBS containing 0.09% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PACSIN1 Antibody, N-terminus detects level of PACSIN1 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN1.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThe antibody recognizes human PACSIN1.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman and mouse. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KIAA1379
      • OTTHUMP00000016231
      • SDPI
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role in vesicle formation and transport. Ref.6

      SUBUNIT STRUCTURE: Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) By similarity.

      SUBCELLULAR LOCATION: CytoplasmBy similarity. Note= Colocalizes with dynamin I at vesicular structures in the cell body and neurites By similarity.

      TISSUE SPECIFICITY: Highly expressed in brain and in a lesser extent in heart, pancreas and liver.

      PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.

      SEQUENCE SIMILARITIES: Belongs to the PACSIN family.

      Contains 1 FCH domain.

      Contains 1 SH3 domain.
      Molecular Weight~57 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Western blot on mouse brain lysate using a 1:100 - 1:500 dilution of Anti-PACSIN1.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      AB10439 04053252472381

      Documentation

      Anti-PACSIN1 Antibody, NT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-PACSIN1 Antibody, NT Certificates of Analysis

      TitleLot Number
      Anti-PACSIN1, N-terminus 2485883
      Anti-PACSIN1, N-terminus - 2316782 2316782
      Anti-PACSIN1, N-terminus - 3026959 3026959
      Anti-PACSIN1, N-terminus - NG1609560 NG1609560
      Anti-PACSIN1, N-terminus -2649152 2649152
      Anti-PACSIN1, N-terminus -2660629 2660629
      Anti-PACSIN1, N-terminus -2661572 2661572
      Anti-PACSIN1, N-terminus -2720351 2720351
      Anti-PACSIN1, N-terminus -2811632 2811632