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MABN1190 Anti-PSD95 Antibody, clone 1A8.1

Anti-PSD95 Antibody, clone 1A8.1 is an antibody against PSD95 for use in Western Blotting, Immunohistochemistry.

Anti-PSD95 Antibody, clone 1A8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: DLG4, PSD95 UniProt Number: P78352
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MABN1190
100 μg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1190
      DescriptionAnti-PSD95 Antibody, clone 1A8.1
      Alternate Names
      • Disks large homolog 4
      • Postsynaptic density protein 95
      • PSD-95
      • Synapse-associated protein 90
      • SAP-90
      • SAP90
      Background InformationDisks large homolog 4 (UniProt P78352; also known as Postsynaptic density protein 95, PSD-95, SAP-90, SAP90, Synapse-associated protein 90) is encoded by the DLG4 (also known as PSD95) gene (Gene ID 1742) in human. PSD-95 belong to the family of membrane-associated guanylate kinases (MAGUKs), which also include PSD-93, SAP97 and SAP102. PSD95 is predominantly expressed in the hippocampus CA1 region and prefrontal cortex of the brain, where it localizes in a somatodendritic pattern in the post-synaptic membrane and in presynaptic axon terminals of inhibitory neurons. PDS-95 is the major scaffolding protein in the excitatory postsynaptic density (PSD) and a potent regulator of synaptic strength via interactions with a diverse PSD proteins, including NMDA receptors (NMDARs), AMPA receptor (AMPAR) complexes via Stargazin/TARP, adhesion molecules, as well as other scaffolding proteins, such as GKAP and Shank. PSD95 and neuronal nitric-oxide synthase (nNOS) interaction plays a role in maintaining hypersensitivity in acute and chronic pain. In addition, the assembly of the GluR6-PSD95-CaMKII complex is implicated as a majore signaling module that mediates injury induced by brain ischemia by facilitating GluR6 serine phosphorylation by CaMKII and the activation of JNK.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PSD95 Antibody, clone 1A8.1 is an antibody against PSD95 for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot PSD95 in human cerebral cortex and cerebellum tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the region between PDZ domain 2 & 3 of human PSD95.
      EpitopeRegion between PDZ domain 2 & 3.
      Clone1A8.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 1A8.1 epitope sequence is present in all spliced isoforms of human, mouse, and rat PSD95 reported by UniProt (P78352, Q62108, P31016).
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DLG4
      • PSD95
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~80 kDa observed. 80.50/80.47/80.47 kDa human/mouse/rat isoform 1; PSD95-alpha), 85.43/85.42 kDa (human/mouse isoform 2; PSD95-beta), 80.13/80.10 kDa (human/mouse isoform 3) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat hippocampus tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected PSD95 in 10 µg of rat hippocampus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABN1190 04055977350999

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies