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MABC553 Anti-Pim-1 Antibody, C-terminus, clone 19F7

Anti-Pim-1 Antibody, C-terminus, clone19F7 is an antibody against Pim-1 for use in Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation and Immunocytochemistry.

Anti-Pim-1 Antibody, C-terminus, clone 19F7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PIM1 UniProt Number: P11309
MABC553
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), IP, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC553
      DescriptionAnti-Pim-1 Antibody, C-terminus, clone 19F7
      Alternate Names
      • Serine/threonine-protein kinase pim-1
      Background InformationPim-1 is a serine/threonine protein kinase encoded by the PIM1 (or PIM) gene in human. Pim-1 is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Pim-1 Antibody, C-terminus, clone19F7 is an antibody against Pim-1 for use in Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Pim-1 in human liver and human prostate cancer section tissue.
      Immunoprecipitation Analysis: A representative lot immunoprecipitated Pim-1 in Transfected Hek293 (Cen, B., et al. (2010). Journal of Biol. Chem. 285(38): 29128-29137).
      Immunocytochemistry Analysis: A representative lot detected Pim-1 in UT-SCC-12A UT-SCC-22 and UT-SCC-43A cells treated with EGF (Peltola, K., et al. (2009). NEO Plasia. 11(7):629-636).
      Immunohistochemistry Analysis: A representative lot detected Pim-1 in adipocytic tumors (Nga, M.E., et al. (2010). Int. J. Exp. Path. 91:34-43).
      Western Blotting Analysis: A representative lot detected Pim-1 in SCC-12 cells treated with Pim-1 siRNA (Peltola, K., et al. (2009). NEO Plasia. 11(7):629-636).
      Western Blotting Analysis: A representative lot detected Pim-1 in transfected Hek293 cells (Cen, B., et al. (2010). Journal of Biol. Chem. 285(38): 29128-29137).
      Biological Information
      ImmunogenConjugated linear peptide corresponding to the C-terminus of human Pim-1.
      EpitopeC-terminus
      Clone19F7
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PIM1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~38/41 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Pim-1 in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABC553 04055977159288