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ABS532 Anti-TRIM63 Antibody

This Anti-TRIM63 antibody is validated for use in WB, IH(P) for the detection of TRIM63.

Anti-TRIM63 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Muscle Physiology Gene Symbol: TRIM63, IRF, MURF1, RNF28, SMRZ
UniProt Number: Q969Q1
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ABS532
100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS532
      DescriptionAnti-TRIM63 Antibody
      Alternate Names
      • E3 ubiquitin-protein ligase TRIM63
      • Iris ring finger protein
      • Ring finger protein 28
      • muscle-specific RING finger protein 1
      • muscle-specific RING finger protein 2
      • Tripartite motif-containing protein 63
      • Striated muscle RING zinc finger protein
      • TRIM63
      • IRF
      • MURF1
      • MURF2
      • RNF28
      • SMRZ
      Background InformationTRIM63, also known as E3 ubiquitin-protein ligase TRIM63, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, and encoded by the gene name TRIM63/ IRF/ MURF1/ RNF28/ SMRZ, is a E3 ubiquitin ligase. TRIM63 mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. It also regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. TRIM63 inhibits de novo skeletal muscle protein synthesis under amino acid starvation, regulates proteasomal degradation of cardiac troponin I/TNNI3, and probably of other sarcomeric-associated proteins. TRIM63 may play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. TRIM63 may regulate the organization of myofibrils through TTN in muscle cells. TRIM63 is expressed selectively in heart and skeletal muscle. TRIM63 is also expressed in the iris.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-TRIM63 antibody is validated for use in WB, IH(P) for the detection of TRIM63.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A representative lot of this antibody at 20 µg/mL detected Trim63 protein in human cardio myocyte. Similar staining was observed in human skeletal myocyte tissue at 4 µg/mL dilution
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of Human TRIM63.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRIM63
      • IRF
      • MURF1
      • RNF28
      • SMRZ
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be detected at high antibody concentrations or longer exposures
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting on human skeletal muscle lysate
      Western Blotting Analysis: 1 µg/mL dilution of this antibody detected Trim63 protein in 10 µg of human skeletal muscle lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABS532 04055977122268