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MAB1482-I Anti-Trypsin (Human pancreas) Antibody, clone TRYP11-236.7

Anti-Trypsin, human pancreas, clone TRYP11-236.7, Cat. No. MAB1482-I, is a mouse monoclonal antibody that detects Trypsin and is tested for use in and ELISA.

MAB1482-I
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMAB1482-I
      DescriptionAnti-Trypsin (Human pancreas) Antibody, clone TRYP11-236.7
      Alternate Names
      • Beta-trypsin
      • Cationic trypsinogen
      • Serine protease 1
      • Trypsin I
      Background InformationTrypsin-1 (UniProt: P07477; also known as EC:3.4.21.4, Beta-trypsin, Cationic trypsinogen, Serine protease 1, Trypsin I) is encoded by the PRSS1 (also known as TRP1, TRY1, TRYP1) gene (Gene ID: 5644) in human. Trypsin is pancreatic serine protease that is synthesized as an inactive precursor known as trypsinogen that is processed through the Golgi apparatus and packaged into zymogen granules for secretion by exocytosis. Trypsin-1 is synthesized with a signal peptide (aa 1-15) and a propeptide (trypsin activation peptide; aa 16-23) that are subsequently cleaved off to generate the mature form that can be further cleaved and processed into alpha-trypsin chain 1 (aa 24-122) and alpha-trypsin chain 2 (aa 123-247). Trypsin can be present in a single-chain and a two-chain form, produced by proteolytic cleavage after arginine 122. Trypsin can also undergo sulfation at tyrosine 154 that increases its selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acid lysine or arginine, except when either is followed by proline.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal in buffer containing PBS, pH 7.4, containing no preservatives without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Trypsin, human pancreas, clone TRYP11-236.7, Cat. No. MAB1482-I, is a mouse monoclonal antibody that detects Trypsin and is tested for use in and ELISA.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • ELISA
      Application NotesImmunohistochestry/IH(P): {Solakidi, et al. 2003} 1:100-1:500; formalin fixed, paraffin embedded human tissues; 5 m serial sections; blocking solution 0.5% serum in PBS; overnight incubations; enzymatic detection.

      ELISA: (Dilution is assay based)

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenPurified human pancreatic trypsin.
      EpitopeUnknown
      CloneTRYP11-236.7
      ConcentrationPlease refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone TRYP11-236.7 is a mouse monoclonal antibody that detects human Trypsin-1.
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteHuman
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PRSS1
      • TRP1
      • TRY1
      • TRYP1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight26.56 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in convenient aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MAB1482-I 04065265651400

      Documentation

      Anti-Trypsin (Human pancreas) Antibody, clone TRYP11-236.7 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Trypsin (Human pancreas) Antibody, clone TRYP11-236.7 Certificates of Analysis

      TitleLot Number
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3812534 3812534
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3821633 3821633
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3824801 3824801
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3826008 3826008
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3832604 3832604
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3833209 3833209
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3859743 3859743
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3862767 3862767
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3884784 3884784
      Anti-Trypsin (Human pancreas), clone TRYP11-236.7 - 3898677 3898677
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