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ABT332 Anti-ZEB2 Antibody

Detect ZEB2 using this rabbit polyclonal antibody, Anti-ZEB2 Antibody validated for use in western blotting, ICC & Immunofluorescence.

Anti-ZEB2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: ZEB2, ZFHX1B, SMADIP1, SIP1, SIP-1, ZFX1B UniProt Number: O60315
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ABT332
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT332
      DescriptionAnti-ZEB2 Antibody
      Alternate Names
      • Zinc finger E-box binding homeobox 2
      • Smad interacting-protein 1
      Background InformationZinc finger E-box-binding homeobox 2 (ZEB2), also known as Smad-interacting protein 1 (SIP1, SMADIP1) and Zinc finger homeobox protein 1b (ZFHX1B, ZFX1B), is a transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters and interacts with activated SMADs. ZEB2 has been shown to repress the transcription of the E-cadherin gene and induce epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing in vitro. It is suggested that ZEB2 contributes to tumor progression since it’s been demonstrated to protect cells from DNA damage-induced apoptosis. Recent studies have shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, implying that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Mowat-Wilson syndrome (MWIS), also known as Hirschsprung disease-mental syndrome.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect ZEB2 using this rabbit polyclonal antibody, Anti-ZEB2 Antibody validated for use in western blotting, ICC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunofluorescence
      Application NotesImmunocytochemistry Analysis: 20 µg/mL from a representative lot detected ZEB2 in Jurkat cells.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected ZEB2 in Jurkat cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human ZEB2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • ZEB2
      • ZFHX1B
      • SMADIP1
      • SIP1
      • SIP-1
      • ZFX1B
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~200 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~134 kDa and ~136 kDa. The calculated molecular weight of this protein is 136 kDa, but can be observed at ~200 kDa due to post-translational modification.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected ZEB2 in 15 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABT332 04053252910234

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies