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ABN1658 Anti-pro-TRH

Anti-pro-TRH, Cat. No. ABN1658, is a highly specific rabbit polyclonal antibody, that targets pro- Thyrotropin-releasing hormone and has been tested in Immunofluorescence and Western Blotting.

Anti-pro-TRH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: Trh UniProt Number: P01150
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ABN1658
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIF, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABN1658
      DescriptionAnti-pro-TRH
      Alternate Names
      • anti-thyrotropin-releasing hormone
      • anti-Ps4
      Background InformationPro-thyrotropin-releasing hormone (UniProt: P01150; also known as Pro-TRH, Prothyroliberin, TRH, TSH-releasing factor, Thyrotropin-releasing factor, TRF) is encoded by the Trh gene (Gene ID: 25569) in rat. TRH is a secreted hypothalamic protein that travels across the median eminence to the pituitary via the hypophyseal portal system. It functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. Pro-TRH (TRH-potentiating peptide: Ps4) is co-synthesized with TRH serves as a marker for TRH-containing neurons. Like TRH itself, pro-TRH is biologically active.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-pro-TRH, Cat. No. ABN1658, is a highly specific rabbit polyclonal antibody, that targets pro- Thyrotropin-releasing hormone and has been tested in Immunofluorescence and Western Blotting.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      Application NotesImmunofluorescence Analysis: A representative lot detected pro-TRH in median eminence of rat and L2 spinal cord tissues. (Courtesy of Dr. Martin Wessendorf at University of Minnesota).

      Immunofluorescence Analysis: A representative lot detected pro-TRH in rat brain stem & rat spinal cord tissues. (Wessendorf, M.W., et. al. (1990). J Histochem Cyotchem. 38(12):1859-77).
      Biological Information
      ImmunogenA linear peptide corresponding to 10 amino acids
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects Thyrotropin-releasing hormone-containing neurons in Rat Hypothalamus and spinal cord.
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Predicted to react with mouse due to sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Trh
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~29 kDa observed; 29.28 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat hypothalamus tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected pro-TRH in 10 µg of rat hypothalamus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.

      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABN1658 04054839168710