Millipore Sigma Vibrant Logo

531000 Brk Inhibitor, Cpd 4f - Calbiochem

Overview

Key Specifications Table

Empirical Formula
C₁₇H₁₃N₃O

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.31000.0001
Retrieving availability...
Limited Availability
Limited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531000
      Brand Family Calbiochem®
      SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
      References
      ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.
      Product Information
      FormLight beige powder
      Hill FormulaC₁₇H₁₃N₃O
      Chemical formulaC₁₇H₁₃N₃O
      Quality LevelMQ100
      Biological Information
      Primary TargetBrk
      Primary Target IC<sub>50</sub>3.15 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      5.31000.0001 04055977242485