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Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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A cell permeable, highly potent, and very selective inhibitor of breast tumor kinase (Brk; IC₅₀ = 3.15 nM). Displays anti-proliferative activity against multiple breast cancer cell lines.
More>>A cell permeable, highly potent, and very selective inhibitor of breast tumor kinase (Brk; IC₅₀ = 3.15 nM). Displays anti-proliferative activity against multiple breast cancer cell lines. Less<<
Brk Inhibitor, Cpd 4f - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number
531000
Brand Family
Calbiochem®
Synonyms
PTK6 Inhibitor, Breast Tumor Kinase Inhibitor
References
References
Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett.24, 1948.
Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett.24, 1948.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-September-2014 JSW
Synonyms
PTK6 Inhibitor, Breast Tumor Kinase Inhibitor
Description
A cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).
Form
Light beige powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₇H₁₃N₃O
Purity
≥97% by HPLC
Solubility
DMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
Toxicity
Standard Handling
References
Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett.24, 1948.