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208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-L-Abu-CONH(CH₂)₃-morpholine

Primary Target: calpain 1, calpain 2
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208743
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
145731-49-3C₂₆H₄₀N₄O₆

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208743-5MG
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      Description
      OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
      Catalogue Number208743
      Brand Family Calbiochem®
      SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
      References
      ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
      DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
      Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
      Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
      Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
      James, T., et al. 1998. J. Neurosci. Res. 51, 218.
      Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
      Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Bartus, R.T., et al. 1994. Stroke 25, 2265.
      Product Information
      CAS number145731-49-3
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₆H₄₀N₄O₆
      Chemical formulaC₂₆H₄₀N₄O₆
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 1, calpain 2
      Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      208743-5MG 04055977202809

      Documentation

      Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      208743

      References

      Reference overview
      Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
      DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
      Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
      Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
      Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
      James, T., et al. 1998. J. Neurosci. Res. 51, 218.
      Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
      Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Bartus, R.T., et al. 1994. Stroke 25, 2265.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 JSW
      SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
      DescriptionA cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, active site inhibitor of calpain-1 (Ki = 140 nM) and calpain-2 (Ki = 41 nM). Weakly inhibits cathepsin B (Ki = 6.9 µM). Shown to inhibit calpain-m-mediated degradation of neurofilament protein (NFP) (IC50 = 600 nM). Also shown to exhibit neuroprotective effects in the central nervous system following focal ischemia. Reported to protect against reovirus-induced myocarditis in mice.
      FormWhite to off-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number145731-49-3
      Chemical formulaC₂₆H₄₀N₄O₆
      Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
      DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
      Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
      Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
      Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
      James, T., et al. 1998. J. Neurosci. Res. 51, 218.
      Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
      Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Bartus, R.T., et al. 1994. Stroke 25, 2265.