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232120

Sigma-Aldrich

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

Synonym(s):

Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum

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50 MG
$129.00

$129.00

Estimated to ship onJune 17, 2025

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50 MG
$129.00

About This Item

Linear Formula:
Pt(NH3)2Cl2
CAS Number:
15663-27-1
MDL number:
MFCD00011623
UNSPSC Code:
12352200
NACRES:
NA.77

$129.00

Estimated to ship onJune 17, 2025

Request a Bulk Order

Product Name

Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

Quality Level

100

description

Merck USA index - 14, 2317

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

yellow

solubility

PBS with 140 mM NaCl: 1 mg/mL
water with 154 mM NaCl: 1 mg/mL
DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/2Cl.2H3N.Pt/h;;2*1H3;

InChI key

JFUARQHXOQHNLK-UHFFFAOYSA-N

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This Item
PHR16241134357P4394
Cisplatin Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

232120

Cisplatin

Cisplatin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1624

Cisplatin

Cisplatin United States Pharmacopeia (USP) Reference Standard

1134357

Cisplatin

cis-Diammineplatinum(II) dichloride crystalline

P4394

cis-Diammineplatinum(II) dichloride

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

solid

form

-

form

-

form

crystalline

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

200

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

USP

manufacturer/tradename

-

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

storage temp.

-

solubility

PBS with 140 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL, water with 154 mM NaCl: 1 mg/mL

solubility

-

solubility

-

solubility

-

General description

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Induces apoptosis in cancer cells
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

  1. The SDS seems to contain the wrong information. It does not match the information on the vial and on the website.

    1 answer

    1. The Safety Data Sheet document provided on the product detail page is the correct document. Please access document below: https://www.sigmaaldrich.com/US/en/sds/mm/232120

      For further concerns, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquires" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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