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204883 Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

Complement C1-Esterase Inhibitor, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204883
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Overview

Replacement Information

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204883-1MG
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      Description
      OverviewNative, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.
      Catalogue Number204883
      Brand Family Calbiochem®
      References
      ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
      Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Application CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Biological Information
      Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
      Purity≥90% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      204883-1MG 04055977219777

      Documentation

      Complement C1-Esterase Inhibitor, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Complement C1-Esterase Inhibitor, Human Certificates of Analysis

      TitleLot Number
      204883

      References

      Reference overview
      Bowen, B., et al. 2001. Clin. Immunol. 98, 157.
      Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2020 JSW
      DescriptionNative, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
      BackgroundSingle chain glycoprotein present in normal human serum at a concentration of 180 μg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.
      FormLiquid
      FormulationIn PBS, pH 7.3, sterile-filtered through a 0.22 µm filter.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts
      Biological activity≥80% of C1-esterase inhibitor will bind activated C1s.
      PreservativeNone
      CommentsVariables associated with assay conditions will dictate the proper working dilution.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesBowen, B., et al. 2001. Clin. Immunol. 98, 157.
      Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.