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434741 ETYA - CAS 1191-85-1 - Calbiochem

Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.

ETYA - CAS 1191-85-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,8,11,14-Eicosatetraynoic Acid

Primary Target: PLA₂
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434741
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1191-85-1C₂₀H₂₄O₂

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434741-20MG
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      		 Plastic ampoule 20 mg
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      Description
      OverviewCell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. Also acts as a potent modulator of Ca2+ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
      Catalogue Number434741
      Brand Family Calbiochem®
      Synonyms5,8,11,14-Eicosatetraynoic Acid
      References
      ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
      Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
      Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
      Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
      Product Information
      CAS number1191-85-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₂₄O₂
      Chemical formulaC₂₀H₂₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPLA₂
      Primary Target IC<sub>50</sub>8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      434741-20MG 04055977210286

      Documentation

      ETYA - CAS 1191-85-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ETYA - CAS 1191-85-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      434741

      References

      Reference overview
      Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
      Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
      Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
      Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-August-2008 RFH
      Synonyms5,8,11,14-Eicosatetraynoic Acid
      DescriptionCell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. A potent modulator of Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.
      FormOff-white solid
      CAS number1191-85-1
      Chemical formulaC₂₀H₂₄O₂
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO or Ethanol (20 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHonda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
      Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
      Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
      Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.