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341220 Exo1 - CAS 75541-83-2 - Calbiochem

A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells by inducing tubulation and collapsing of the Golgi membrane.

Exo1 - CAS 75541-83-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I

Primary Target: Golgi ARF1 GTPase
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341220
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
75541-83-2C₁₅H₁₂FNO₃

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341220-25MG
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      Description
      OverviewA cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies.
      Catalogue Number341220
      Brand Family Calbiochem®
      Synonyms2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
      References
      ReferencesFeng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.
      Product Information
      CAS number75541-83-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₂FNO₃
      Chemical formulaC₁₅H₁₂FNO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGolgi ARF1 GTPase
      Primary Target IC<sub>50</sub>20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      341220-25MG 04055977215496

      Documentation

      Exo1 - CAS 75541-83-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Exo1 - CAS 75541-83-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      341220

      References

      Reference overview
      Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
      DescriptionA cell-permeable methylanthranilate analog that reversibly blocks vesicular traffic from the ER to the Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and re-directing the traffic back to the ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor, Brefeldin A (BFA) (Cat. No. 203729), the effects appear to be limited to the Golgi, as no effects are detected on endocytic organelles, such as endosomes and trans-Golgi network (TGN). The inhibitory mechanism and target(s) appear to be different from those of BFA, thus making it a valuable alternative that complements BFA in membrane trafficking studies.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number75541-83-2
      Chemical formulaC₁₅H₁₂FNO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml), DMF (25 mg/ml), Methanol (5 mg/ml), or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesFeng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.