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504045 Focal Adhesion Kinase Inhibitor III - CAS 1426683-53-5 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
1426683-53-5C₂₂H₂₆N₄O₂S

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable pyrazolobenzothiazinedioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50 = 7.1 µM with 30 min inhibitor preincubation), while exhibiting little activity toward Akt1, Aurora B, HER2, MEK1, p38α, Pyk2, or Src even at concentrations as high as 10 µM.
      Catalogue Number504045
      Brand Family Calbiochem®
      SynonymsFAK Inhibitor III, N-(4-tert-Butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine-4,4-dioxide
      References
      ReferencesTomita, N., et al. 2013. Bioorg. Med. Chem. Lett. 23, 1779.
      Product Information
      CAS number1426683-53-5
      FormOff-white powder
      Hill FormulaC₂₂H₂₆N₄O₂S
      Chemical formulaC₂₂H₂₆N₄O₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetFAK
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      5.04045.0001 04055977264272