344092 Sigma-AldrichFormin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem
Formin FH2 Domain Inhibitor, SMIFH2, CAS 340316-62-3, is a cell-permeable inhibitor of formin-mediated actin nucleation (IC50 ~15 µM) and formin-mediated elongation of actin filaments.
More>> Formin FH2 Domain Inhibitor, SMIFH2, CAS 340316-62-3, is a cell-permeable inhibitor of formin-mediated actin nucleation (IC50 ~15 µM) and formin-mediated elongation of actin filaments. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Small Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 340316-62-3 | C₁₅H₉BrN₂O₃S |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 344092-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 µM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 µM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 µM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 µM) in NIH 3T3 fibroblast cultures. |
| Catalogue Number | 344092 |
| Brand Family | Calbiochem® |
| Synonyms | Small Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV |
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| References | Rizvi, S.A., et al. 2009. Chem. Biol. 16, 1158. |
| Product Information | |
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| CAS number | 340316-62-3 |
| Form | Dark to deep green solid |
| Hill Formula | C₁₅H₉BrN₂O₃S |
| Chemical formula | C₁₅H₉BrN₂O₃S |
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| Quality Level | MQ100 |
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| Purity | ≥98% by HPLC (sum of two geometrical isomers) |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 344092-10MG | 04055977194579 |
Documentation
Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem SDS
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Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 344092 |
References
| Reference overview |
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| Rizvi, S.A., et al. 2009. Chem. Biol. 16, 1158. |