371830 Sigma-AldrichGPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem
The GPR40 Antagonist, GW1100, also referenced under CAS 306974-70-9, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The GPR40 Antagonist, GW1100, also referenced under CAS 306974-70-9, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 306974-70-9 | C₂₇H₂₅FN₄O₄S |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 371830-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 (Cat. No. 371706) and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. |
| Catalogue Number | 371830 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone, SB376752 |
| References | |
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| References | Stoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994. Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619. |
| Product Information | |
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| CAS number | 306974-70-9 |
| Form | White powder |
| Hill Formula | C₂₇H₂₅FN₄O₄S |
| Chemical formula | C₂₇H₂₅FN₄O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 371830-10MG | 04055977213478 |
Documentation
GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem SDS
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GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 371830 |
References
| Reference overview |
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| Stoddart, L.A., et al. 2007. Mol. Pharmacol. 71, 994. Briscoe, C.P., et al. 2006. Br. J. Pharmacol. 148, 619. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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