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361548 GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor

Primary Target: GSK-3β
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361548
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
99-73-0C₈H₆Br₂O

Pricing & Availability

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361548-5MG
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      Description
      OverviewA phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
      Catalogue Number361548
      Brand Family Calbiochem®
      Synonymsα-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
      References
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Product Information
      CAS number99-73-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₆Br₂O
      Chemical formulaC₈H₆Br₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3β
      Primary Target IC<sub>50</sub>0.5 µM against GSK-3β
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAM6950000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      361548-5MG 04055977214048

      Documentation

      GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      361548

      References

      Reference overview
      Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-July-2008 RFH
      Synonymsα-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
      DescriptionA phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC50 = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number99-73-0
      RTECSAM6950000
      Chemical formulaC₈H₆Br₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.