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361551 GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem

The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime

Primary Target: GSK-3α/β
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361551
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
740841-15-0C₁₈H₁₂BrN₃O₃

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      Description
      OverviewAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
      Catalogue Number361551
      Brand Family Calbiochem®
      Synonyms(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
      References
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number740841-15-0
      ATP CompetitiveN
      FormDark purple solid
      Hill FormulaC₁₈H₁₂BrN₃O₃
      Chemical formulaC₁₈H₁₂BrN₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>10 nM against GSK-3α/β
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      361551-1MG 04055977214093

      Documentation

      GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      361551

      References

      Reference overview
      Knockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms(2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
      DescriptionAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 µM, 4.3 µM, and 63 µM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 µM). Yields BIO (Cat. No. 361550) upon hydrolysis.
      FormDark purple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number740841-15-0
      Chemical formulaC₁₈H₁₂BrN₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml). Limited solubility in aqueous buffers; serial dilutions in DMSO may be required prior to dilution in buffer.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.