361546 Sigma-AldrichGSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem
The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: L803-mts, Myr-N-GKEAPPAPPQSpP-NH₂
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₆₆H₁₁₀N₁₅O₂₀P |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 361546-1MG |
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Plastic ampoule | 1 mg |
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| Description | |
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| Overview | A cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50 = 40 µM). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displays in vivo stability. |
| Catalogue Number | 361546 |
| Brand Family | Calbiochem® |
| Synonyms | L803-mts, Myr-N-GKEAPPAPPQSpP-NH₂ |
| References | |
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| References | Plotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974. |
| Product Information | |
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| ATP Competitive | N |
| Declaration | This product is covered by one or more US patents and/or patent applications and foreign counter-parts owned by Tel Aviv University Future Technology LP, a limited partnership formed under the laws of Israel. Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey the right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR USE IN HUMANS. For information on purchasing a license to this product for purposes other than research, contact VP Business Development, Ramot at Tel Aviv University Ltd., Tel Aviv University, Licensor-Aviv, Tel Aviv 61392, Israel, Phone: +972 3 640 6608; Fax: +972 3 640 6675. |
| Form | Lyophilized white solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₆₆H₁₁₀N₁₅O₂₀P |
| Chemical formula | C₆₆H₁₁₀N₁₅O₂₀P |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Gsk-3β |
| Primary Target IC<sub>50</sub> | 40 µM against Gsk-3β |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Myr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO₃H)-Pro-NH₂ |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 361546-1MG | 04055977214024 |
Documentation
GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem SDS
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GSK-3β Peptide Inhibitor, Cell-permeable - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 361546 |
References
| Reference overview |
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| Plotkin, B., et al. 2003. J. Pharmacol. Exp. Ther. 305, 974. |