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345701 Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Guttic Acid, β-Guttiferin

Primary Target: Caspase activator and an apoptosis inducer
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345701
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
2752-65-0C₃₈H₄₄O₈

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345701-25MG
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      Description
      OverviewA cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).
      Catalogue Number345701
      Brand Family Calbiochem®
      SynonymsGuttic Acid, β-Guttiferin
      References
      ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
      Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
      Asano, J., et al. 1996. Phytochemistry 41, 815.
      Product Information
      CAS number2752-65-0
      ATP CompetitiveN
      FormAmorphous orange solid
      Hill FormulaC₃₈H₄₄O₈
      Chemical formulaC₃₈H₄₄O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaspase activator and an apoptosis inducer
      Primary Target IC<sub>50</sub>MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSPB9268200
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      345701-25MG 04055977193787

      Documentation

      Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      345701

      References

      Reference overview
      Prasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
      Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
      Asano, J., et al. 1996. Phytochemistry 41, 815.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-July-2017 JSW
      SynonymsGuttic Acid, β-Guttiferin
      DescriptionA cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
      FormAmorphous orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2752-65-0
      RTECSPB9268200
      Chemical formulaC₃₈H₄₄O₈
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (10 mg/ml) or Ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 4361
      ReferencesPrasad, S., et al. 2011. Cancer Prev. Res. 4, 1084.
      Guo, Q.L., et al. 2004. Acta Pharmacol. Sin. 25, 769.
      Asano, J., et al. 1996. Phytochemistry 41, 815.