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14-645M IRR Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.

14-645M
250 µg  Also available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-645M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIRR Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human IRR, amino acids 944-1266. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman IRR, amino acids 944-1266 expressed by baculovirus in Sf21 cells.
      Entrez Gene Number
      Gene Symbol
      • INSRR
      • IRR
      Protein TargetIRR
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14616 # This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
      SIZE: 1297 amino acids; 143720 Da
      SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P14616 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 protein kinase domain.
      Molecular Weight37.9kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-645) and in bulk (cat#14-645-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-645M 04053252924538

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-645 IRR Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases