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555552 InSolution™ Rho Kinase Inhibitor - Calbiochem

The InSolution™ Rho Kinase Inhibitor controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: ROCK
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555552
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₆H₂₁N₃O₂S • 2HCl

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
555552-500UG
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      		 Plastic ampoule 500 μg
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      Description
      Catalogue Number555552
      Brand Family Calbiochem®
      References
      ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
      Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
      Hill FormulaC₁₆H₂₁N₃O₂S • 2HCl
      Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetROCK
      Primary Target K<sub>i</sub>1.6 nM against Rho-associated kinase (ROCK)
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      555552-500UG 04055977268423

      Documentation

      InSolution™ Rho Kinase Inhibitor - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Rho Kinase Inhibitor - Calbiochem Certificates of Analysis

      TitleLot Number
      555552

      References

      Reference overview
      Ikenoya, M., et al. 2002. J. Neurochem. 81, 9.
      Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      DescriptionA cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki = 630 nM for PKA, 9.27 µM for PKC, and 10.1 µM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50 = 2.5 µM). Reported to be a more potent and selective inhibitor than Y-27632 (Cat. No. 688000 & 688001).
      FormLiquid
      FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful
      ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
      Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.