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407615 Interleukin-1β, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIL-1β

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407615
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Overview

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407615-5UG
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      Description
      OverviewRecombinant, human interleukin-1β expressed in E. coli. Major form of interleukin-1 secreted by monocytes and macrophages. Induces nitric oxide synthase in pancreatic and smooth muscle cells and suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing.
      Catalogue Number407615
      Brand Family Calbiochem®
      SynonymsrhIL-1β
      References
      ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Kunz, D., et al. 1994. Biochem. J. 304, 337.
      Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
      Dinarello, C>A> 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.
      Product Information
      CAS number97599-21-8
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = <12 pg/ml as measured in a cell proliferation assay using the murine T-cell line, D10.G4.1 (Symons, J.A. et al. 1987)
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNM9740000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      407615-5UG 04055977211320

      Documentation

      Interleukin-1β, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-1β, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407615

      References

      Reference overview
      Chun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Kunz, D., et al. 1994. Biochem. J. 304, 337.
      Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
      Dinarello, C>A> 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      SynonymsrhIL-1β
      DescriptionRecombinant, human interleukin-1β expressed in E. coli. Major form of interleukin-1 secreted by monocytes and macrophages. IL-1β is activated by proteolytic cleavage of the precursor molecule. Increases nitric oxide production in smooth muscle cells and suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Induces nitric oxide synthase in insulin-producing cells. 1 µg of IL-1β corresponds to 1.9 x 105 WHO units.
      FormLyophilized
      FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
      CAS number97599-21-8
      RTECSNM9740000
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg IL-1β
      Biological activityED₅₀ = <12 pg/ml as measured in a cell proliferation assay using the murine T-cell line, D10.G4.1 (Symons, J.A. et al. 1987)
      SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 4993
      ReferencesChun, S.Y., et al. 1995. Endocrinology 136, 3120.
      Kunz, D., et al. 1994. Biochem. J. 304, 337.
      Eizirik, D.L., et al. 1993. FEBS Lett. 317, 62.
      Dinarello, C>A> 1991. Blood 77, 1627.
      Casagli, M.C., et al. 1989. Biochem. Biophys. Res. Commun. 162, 357.
      Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.

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