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420135 JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem

JNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide

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420135
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      Description
      OverviewA cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
      Catalogue Number420135
      Brand Family Calbiochem®
      SynonymsN-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
      References
      ReferencesVivanco, I., et al. 2007. Cancer Cell 11, 555.
      Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
      Product Information
      CAS number894804-07-0
      ATP CompetitiveY
      FormBrown solid
      Hill FormulaC₁₈H₂₀N₄O₄
      Chemical formulaC₁₈H₂₀N₄O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationJNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).
      Biological Information
      Primary TargetJNK
      Primary Target K<sub>i</sub>2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      420135-5MG 04055977187656

      Documentation

      JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      420135

      References

      Reference overview
      Vivanco, I., et al. 2007. Cancer Cell 11, 555.
      Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsN-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
      DescriptionA cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number894804-07-0
      Chemical formulaC₁₈H₂₀N₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVivanco, I., et al. 2007. Cancer Cell 11, 555.
      Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.