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524644 L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

A component of membrane-bound receptors in association with phospholipase C (PLC).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PIP₂

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524644
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
383907-42-4C₄₇H₈₂O₁₉P₃ · 3NH₄

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      524644-1MG
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          Description
          OverviewA component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
          Catalogue Number524644
          Brand Family Calbiochem®
          SynonymsPIP₂
          References
          ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
          Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
          Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
          Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
          Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
          Williamson, J.R. 1986. Hypertension 8, 140.
          Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
          Product Information
          CAS number383907-42-4
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₄₇H₈₂O₁₉P₃ · 3NH₄
          Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetBrain phospholipase D (PLD)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          524644-100UG 04055977197624
          524644-1MG 04055977197617

          Documentation

          L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          524644

          References

          Reference overview
          Baukrowitz, T., et al. 1998. Science 282, 1141.
          Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
          Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
          Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
          Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
          Williamson, J.R. 1986. Hypertension 8, 140.
          Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-August-2015 JSW
          SynonymsPIP₂
          DescriptionA component of membrane-bound receptors in association with phospholipase C. Hydrolysis of PIP2 yields IP3 and diacylglycerol, causing the release of intracellular Ca2+ and activation of protein kinase C. Potently stimulates phospholipase D activity in vitro in brain tissue. A substrate for PI 3-kinase. Antagonist of ATP inhibtion of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.

          Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number383907-42-4
          Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityCHCl₃ (50 mg/ml) or H₂O (10 mg/ml)
          Storage Protect from light
          ≤ -70°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
          Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
          Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
          Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
          Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
          Williamson, J.R. 1986. Hypertension 8, 140.
          Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.