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480743 Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem

A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx

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480743
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
832115-62-5C₁₁H₁₀N₂O₂S

Pricing & Availability

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480743-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
      Catalogue Number480743
      Brand Family Calbiochem®
      SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
      References
      ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
      Zhang, L., et al. 2011. Differentiation 81, 233.
      Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
      Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
      Product Information
      CAS number832115-62-5
      FormOff-white solid
      Hill FormulaC₁₁H₁₀N₂O₂S
      Chemical formulaC₁₁H₁₀N₂O₂S
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      480743-10MG 04055977201444

      Documentation

      Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      480743

      References

      Reference overview
      Dioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
      Zhang, L., et al. 2011. Differentiation 81, 233.
      Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
      Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-June-2013 JSW
      SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
      DescriptionA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number832115-62-5
      Chemical formulaC₁₁H₁₀N₂O₂S
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
      Zhang, L., et al. 2011. Differentiation 81, 233.
      Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
      Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.