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539109 PAR-2 Agonist I - Calbiochem

The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

PAR-2 Agonist I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide

Primary Target: PAR-2
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539109
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₁H₅₃N₉O₇

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
539109-1MG
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      539109-5MG
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          Description
          OverviewThe native PAR-2-specific agonist, SLIGRL-NH2, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2-/- mice. Reactive towards human, rat, and murine PAR-2.
          Catalogue Number539109
          Brand Family Calbiochem®
          SynonymsProteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide
          References
          ReferencesKawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108.
          Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098.
          Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₁H₅₃N₉O₇
          Chemical formulaC₃₁H₅₃N₉O₇
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPAR-2
          Primary Target IC<sub>50</sub>EC50 = 253 nM as PAR-2-specific agonist using HCT-15 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide Sequence2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          539109-1MG 04055977195309
          539109-5MG 04055977195316

          Documentation

          PAR-2 Agonist I - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          PAR-2 Agonist I - Calbiochem Certificates of Analysis

          TitleLot Number
          539109

          References

          Reference overview
          Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108.
          Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098.
          Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-September-2008 RFH
          SynonymsProteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide
          DescriptionNative proteinase activated receptor-2- (PAR-2) specific agonist, SLIGRL-NH2, modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM in HCT-15 cells) in vitro. Also induces PAR-2-mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo. Exhibits no effects on PAR-2-/- mice. Reactive towards human, rat, and mouse PAR-2.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₁H₅₃N₉O₇
          Peptide Sequence2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108.
          Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098.
          Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.