554995 Sigma-AldrichRGS Proteins Inhibitor II, CCG-50014 - Calbiochem
The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₁₆H₁₃FN₂O₂S |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 554995-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50 = 0.03, 0.12, 3.5, 11, > 200 and > 200 µM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys− using FCPIA assay, respectively). Shown to block RGS4-Gα0 interaction and repress Gα0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Gα0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50 > 100 µM). A reversible inhibitor of RGS Proteins, CCG-63802 is also available (Cat. No. 554993). |
| Catalogue Number | 554995 |
| Brand Family | Calbiochem® |
| Synonyms | 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione |
| References | |
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| References | Blazer, L.L., et al. 2011. Biochemistry 50, 3181. Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610. |
| Product Information | |
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| Form | White solid |
| Hill Formula | C₁₆H₁₃FN₂O₂S |
| Chemical formula | C₁₆H₁₃FN₂O₂S |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 554995-10MG | 04055977268362 |
Documentation
RGS Proteins Inhibitor II, CCG-50014 - Calbiochem SDS
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RGS Proteins Inhibitor II, CCG-50014 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 554995 |
References
| Reference overview |
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| Blazer, L.L., et al. 2011. Biochemistry 50, 3181. Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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