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553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC23766

Primary Target: Rac1
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553502
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1177865-17-6C₂₄H₃₈Cl₃N₇

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553502-10MG
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      		 Glass bottle 10 mg
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      553502-5MG
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          Description
          OverviewA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
          Catalogue Number553502
          Brand Family Calbiochem®
          SynonymsNSC23766
          References
          ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
          Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
          Product Information
          CAS number1177865-17-6
          ATP CompetitiveN
          FormLyophilized
          Hill FormulaC₂₄H₃₈Cl₃N₇
          Chemical formulaC₂₄H₃₈Cl₃N₇
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetRac1
          Primary Target IC<sub>50</sub>~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          553502-10MG 04055977193626
          553502-5MG 07790788051433

          Documentation

          Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          553502

          References

          Reference overview
          Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
          Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

          Citations

          Title
        • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-February-2012 RFH
          SynonymsNSC23766
          DescriptionA cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
          FormLyophilized
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177865-17-6
          Chemical formulaC₂₄H₃₈Cl₃N₇
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesDwivedi, S., et al. 2010. J. Translational Med. 8, 128.
          Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
          Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
          Citation
        • Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
          		•