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557440 Ru360 - Calbiochem

Ru360, is a cell-permeable oxygen-bridged dinuclear ruthenium amine complex. Binds to mitochondria with high affinity (Kd = 340 pM) and blocks Ca2+ uptake into mitochondria in vitro (IC₅₀ = 184 pM).

Ru360 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃

Primary Target: Ca2+ uptake into mitochondria in vitro
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557440
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂H₂₆Cl₃N₈O₅Ru₂

Pricing & Availability

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557440-1SET
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      		 Glass bottle 1 set
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      557440-500UG
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          		 Plastic ampoule 500 μg
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          Description
          OverviewA cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels.
          Note: 1 set = 10 x 100 µg.
          Catalogue Number557440
          Brand Family Calbiochem®
          Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
          References
          ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
          Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
          Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
          Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
          Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
          Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
          Product Information
          ATP CompetitiveN
          FormGreen solid
          Hill FormulaC₂H₂₆Cl₃N₈O₅Ru₂
          Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCa2+ uptake into mitochondria in vitro
          Primary Target IC<sub>50</sub>184 pM blocking Ca2+ uptake into mitochondria in vitro; and in situ in intact myocytes; Kd = 340 pM for binding mitochondria
          Purity≥97%
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          557440-1SET 07790788051501
          557440-500UG 04055977268089

          Documentation

          Ru360 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ru360 - Calbiochem Certificates of Analysis

          TitleLot Number
          557440

          References

          Reference overview
          Sanchez, J.A., et al. 2001. J. Physiol. 536, 387.
          Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
          Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
          Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
          Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
          Ying, W.-L., et al. 1991. Biochemistry 30, 4949.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-August-2021 JSW
          Synonyms(μ)[(HCO₂)(NH₃)₄Ru]₂OCl₃
          DescriptionA cell-permeable oxygen bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 0.34 nM) and specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (for complete block after incubation with ~10 µM of Ru360 for 30 min. Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction even at micromolar levels.
          FormGreen solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂H₂₆Cl₃N₈O₅Ru₂
          Structure formulaStructure formula
          Purity≥97%
          SolubilityDeoxygenated H₂O (0.5 mg/ml)
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesSanchez, J.A., et al. 2001. J. Physiol. 536, 387.
          Bassani, R.A., et al. 1998. Cell Calcium 23, 433.
          Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223.
          Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379.
          Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799.
          Ying, W.-L., et al. 1991. Biochemistry 30, 4949.