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505896 Sumanirole Maleate - CAS 179386-44-8 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
179386-44-8C₁₁H₁₃N₃O•C₄H₄O₄

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      Glass bottle 5 mg
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      Description
      OverviewAn extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
      Catalogue Number505896
      Brand Family Calbiochem®
      SynonymsDopamine D₂ receptor Agonist, Sumanirole, PNU 95666, PNU95666
      References
      ReferencesAchat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
      McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.
      Product Information
      CAS number179386-44-8
      FormOff-white solid
      Hill FormulaC₁₁H₁₃N₃O•C₄H₄O₄
      Chemical formulaC₁₁H₁₃N₃O•C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetD₂
      Primary Target K<sub>i</sub>9nM
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalog Number GTIN
      5.05896.0001 04055977262506