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579052 TAPI-2 - CAS 187034-31-7 - Calbiochem

TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.

TAPI-2 - CAS 187034-31-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2

Primary Target: MMPs
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579052
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
187034-31-7C₁₉H₃₇N₅O₅

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579052-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612).
      Catalogue Number579052
      Brand Family Calbiochem®
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
      References
      ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
      Product Information
      CAS number187034-31-7
      ATP CompetitiveN
      DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
      FormWhite solid
      Hill FormulaC₁₉H₃₇N₅O₅
      Chemical formulaC₁₉H₃₇N₅O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMPs
      Primary Target IC<sub>50</sub>18 µM against angiotensin converting enzyme
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      579052-1MG 04055977265378

      Documentation

      TAPI-2 - CAS 187034-31-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TAPI-2 - CAS 187034-31-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      579052

      References

      Reference overview
      Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
      DescriptionA hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number187034-31-7
      Chemical formulaC₁₉H₃₇N₅O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityEthanol (5 mg/ml) or H₂O (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.