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GF314 TNF- α Protein, Human Recombinant Animal Free

Tumor necrosis factor alpha (TNF-α), also known as cachectin & TNFSF1A, is the prototypic ligand of the TNF superfamily. Recombinant animal free human TNF-α is manufactured using all non-animal reagents.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01375 Entrez Gene Number: NM_000594.2
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GF314
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SourcePurity
      E. coli Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF314
      DescriptionTNF- α Protein, Human Recombinant Animal Free
      Alternate Names
      • Tumor Necrosis Factor Alpha
      • TNFa
      • TNF-alpha
      • Cachectin
      • TNFSF1A
      Background InformationTumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
      References
      Product Information
      Formulation
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      ApplicationTumor necrosis factor alpha (TNF-α), also known as cachectin & TNFSF1A, is the prototypic ligand of the TNF superfamily. Recombinant animal free human TNF-α is manufactured using all non-animal reagents.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
      SourceE. coli
      Cross ReactivityCow, Monkey, Mouse, Rat, Sheep
      Entrez Gene Number
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      GF314 04053252691508

      Documentation

      TNF- α Protein, Human Recombinant Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      TNF- α Protein, Human Recombinant Animal Free Certificates of Analysis

      TitleLot Number
      Recombinant Animal Free -2514227 2514227
      Recombinant Animal Free -2575771 2575771
      Recombinant Animal Free -2575812 2575812
      Recombinant Animal Free -2580714 2580714
      Recombinant Animal Free -2594438 2594438
      Recombinant Animal Free -2620659 2620659
      Recombinant Animal Free -2622614 2622614
      Recombinant Animal Free -2659616 2659616
      Recombinant Animal Free -2661510 2661510
      Recombinant Animal Free -2665793 2665793
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