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108219 Tris(hydroxymethyl)aminomethane hydrochloride

Overview

Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

Pricing & Availability

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1082191000
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      1082191003
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          1.08219.5000
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              1082199010
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                  1082199012
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                      Bucket, plastic 12 kg
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                      1082199013
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                          1082199050
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                              Description
                              Catalogue Number108219
                              SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                              DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                              References
                              Product Information
                              CAS number1185-53-1
                              EC number214-684-5
                              Hill FormulaC₄H₁₁NO₃˙ ClH
                              Chemical formulaC₄H₁₁NO₃*ClH
                              Molar Mass157.60 g/mol
                              HS Code2922 19 99
                              Structure formula ImageStructure formula Image
                              Quality LevelMQ500
                              Applications
                              Biological Information
                              Physicochemical Information
                              Density1.28 g/cm3 (20.2 °C)
                              Melting Point150.7 °C
                              pH value4.2 (100 g/l, H₂O, 20 °C)
                              Vapor pressure<0.1 hPa (50 °C)
                              Solubility561 g/l soluble
                              Dimensions
                              Materials Information
                              Toxicological Information
                              Safety Information according to GHS
                              Storage class10 - 13 Other liquids and solids
                              WGKWGK 1 slightly hazardous to water
                              Disposal3
                              Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                              Safety Information
                              Product Usage Statements
                              Storage and Shipping Information
                              StorageStore at +15°C to +25°C.
                              Packaging Information
                              Transport Information
                              Supplemental Information
                              Specifications
                              Appearancewhite to almost white, crystalline powder
                              Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
                              Identity (IR-spectrum)conforms
                              pH-value (0.5 mol/l, water)3.5 - 5.0
                              Melting point147 - 153 °C
                              UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                              UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                              UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                              UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                              UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                              Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                              Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                              Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                              Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                              Other residual solvents (ICH Q3C)excluded by manufacturing process
                              Sulfated ash≤ 0.03
                              Loss on Drying (105°C)≤ 0.5
                              Endotoxins< 2.5
                              Total aerobic microbial count≤ 10²
                              Total yeast and mould count
                              ≤ 10²
                              Salmonella spp.
                              absent in 10 g
                              E.coli
                              absent in 1 g
                              Staphylococcus aureus
                              absent in 1 g
                              Pseudomonas aeruginosa
                              absent in 1 g
                              Candida albicans
                              absent in 1 g
                              Bile tolerante gram negative bacteria
                              absent in 1 g
                              DNases (Exo- and endonucleases)
                              not detected
                              Proteases
                              not detected
                              RNases
                              not detected
                              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                              Total yeast and mould count
                              ≤ 10²
                              Salmonella spp.
                              absent in 10 g
                              E.coli
                              absent in 1 g
                              Staphylococcus aureus
                              absent in 1 g
                              Pseudomonas aeruginosa
                              absent in 1 g
                              Candida albicans
                              absent in 1 g
                              Bile tolerante gram negative bacteria
                              absent in 1 g
                              DNases (Exo- and endonucleases)
                              not detected
                              Proteases
                              not detected
                              RNases
                              not detected
                              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                              Global Trade Item Number
                              Catalog Number GTIN
                              1082191000 04022536101811
                              1082191003 04027269196462
                              1.08219.5000 04022536532899
                              1082199010 04022536702742
                              1082199012 04027269285586
                              1082199013 04027269285593
                              1082199050 04054839392443

                              Documentation

                              Material Qualification Dossier

                              TitleVersion
                              6.0

                              Quality Management Dossier (Open Access)

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                              Operational Excellence Dossier

                              Title

                              Tris(hydroxymethyl)aminomethane hydrochloride SDS

                              Title

                              Safety Data Sheet (SDS) 

                              Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                              Product Number PackagingSpecificationLot Number
                              1082191000 Plastic bottlePDF Specification Document
                              1082191003 Plastic bottlePDF Specification Document
                              1.08219.5000 Plastic bottlePDF Specification Document
                              1082199010 Plastic drumPDF Specification Document
                              1082199012 Bucket, plasticPDF Specification Document
                              1082199013 Bucket, plasticPDF Specification Document
                              1082199050 Plastic drumPDF Specification Document

                              Certificates

                              Title