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Histones and Histone Modifications | Life Science Research | MilliporeSigma
Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. MilliporeSigma grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. MilliporeSigma offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today. -
Histone Peptide Arrays | Life Science Research | MilliporeSigma
Histone peptide arrays are essential screening tools to evaluate the specificity and cross-reactivity of antibodies against histones H2A, H2B, H3, H4, and their post-translational modifications.The arrays are designed on PVDF membranes for a simple Western blot-like assay. -
Epigenetics and Nuclear Function | Life Science Research | MilliporeSigma
Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. Researchers can count on high quality reagents and expert support for their studies of gene regulation.