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Genomic instability | Life Science Research | MilliporeSigma
Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators.
Epigenetics and Nuclear Function | Life Science Research | MilliporeSigma
Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. Researchers can count on high quality reagents and expert support for their studies of gene regulation.
Telomere Attrition | Life Science Research | MilliporeSigma
Telomerase attrition expression is silenced in many adult cells, to curb rampant cell proliferation and tumorigenesis, and so telomeres get progressively shorter with age.