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  • Ubiquitin Antibodies | Life Science Research | MilliporeSigma

    Our tools for studying ubiquitination will help you understand the biological role and importance of the ubiquitin-proteasome pathway that has been implicated in several forms of malignancy and in the pathogenesis of several genetic diseases.

  • Discovery & Development Solutions | Life Science Research | MilliporeSigma

    Speed your time to discovery by leveraging our target profiling services, multiplex and traditional immunoassays, and clinical lab contract services that help you prioritize potential drug candidates, screen many biomarkers simultaneously, and conduct research and clinical studies. Our offerings encompass: drug discovery, target profiling and multiplexing.

  • Proteins and Enzymes | Life Science Research | MilliporeSigma

    Proteins and enzymes are vital parts of organisms participating in almost every process and performing functions that include transport of molecules, DNA replication, catalysis, and responding to stimuli. We offer thousands of highly qualified proteins within an extensive group of subcategories.

  • Histones and Histone Modifications | Life Science Research | MilliporeSigma

    Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. Understanding histone modifications is key to uncovering epigenetic mechanisms of gene regulation. MilliporeSigma grasps the complexity of this research and provides a growing line of kits, antibodies, and assays for studying histones and their modifications. MilliporeSigma offers over 600 validated antibodies, recombinant proteins, and kits to analyze histone and histone-variant phosphorylation, methylation, acetylation, ubiquitination, and citrullination-the most widely studied histone modifications in epigenetics today.

  • Chromatin Associated Proteins | Life Science Research | MilliporeSigma

    Chromatin is a complex molecule that can be found in either an open decondensed or active state (euchromatin) or in a tightly compacted inactive state (heterochromatin). MilliporeSigma also offers a wide selection of ChIP-qualified antibodies against modified and unmodified histones, transcription factors, chromatin modifying proteins and other key chromatin associated proteins.