Prion Diseases
The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission. In prion diseases, such as Creutzfeld-Jakob Disease (CJD), Gerstmann-Straussler- Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome, and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles, and amyloid deposits. Browse Related Products
Immunohistochemistry: 1:50 working dilutions of anti-Prion Protein, clone 2G11 localizes prion protein in rat brain paraffin embedded tissue (High & Low Magnification).

Prion Diseases

The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission. In prion diseases, such as Creutzfeld-Jakob Disease (CJD), Gerstmann-Straussler- Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome, and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles, and amyloid deposits.

Browse Related Products

Immunohistochemistry: 1:50 working dilutions of anti-Prion Protein, clone 2G11 localizes prion protein in rat brain paraffin
embedded tissue (High & Low Magnification).