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343781 ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ω-CgTx GVIA

Primary Target: Voltage-activated N-type Ca2+ channels
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343781
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
106375-28-4C₁₂₀H₁₈₂N₃₈O₄₃S₆

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      Description
      OverviewA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
      Catalogue Number343781
      Brand Family Calbiochem®
      Synonymsω-CgTx GVIA
      References
      ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
      Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
      Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
      Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
      Protti, D.A., et al. 1991. Brain Res. 557, 336.
      Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
      Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
      Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
      Product Information
      CAS number106375-28-4
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormLyophilized
      Hill FormulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
      Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVoltage-activated N-type Ca2+ channels
      Primary Target IC<sub>50</sub>21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 45-36/37/39

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      End use certificateY
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      343781-100UG 04055977195125

      Documentation

      ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      343781

      References

      Reference overview
      Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
      Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
      Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
      Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
      Protti, D.A., et al. 1991. Brain Res. 557, 336.
      Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
      Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
      Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2008 RFH
      Synonymsω-CgTx GVIA
      DescriptionA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
      FormLyophilized
      CAS number106375-28-4
      Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
      Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
      Purity≥98% by HPLC
      SolubilityH₂O (250 µg/ml) or aqueous buffers
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Highly Toxic
      ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
      Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
      Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
      Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
      Protti, D.A., et al. 1991. Brain Res. 557, 336.
      Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
      Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
      Abe, T., et al. 1986. Neurosci. Lett. 71, 203.