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ABN332 Anti-BICD2 Antibody

Anti-BICD2 detects levels of BICD2 proteins & has been published & validated for use in WB & IHC.

Anti-BICD2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: BICD2 UniProt Number: Q8TD16
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ABN332
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN332
      DescriptionAnti-BICD2 Antibody
      Alternate Names
      • Bicaudal D homolog 2
      • Bic-D 2
      • BICD2
      Background InformationBICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human lung tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-BICD2 detects levels of BICD2 proteins & has been published & validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected BICD2 in human cerebellum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human BICD2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody will not cross-react with BICD1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • BICD2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~100 kDa observed. Uniprot describes two isoforms at ~94 kDa and ~97 kDa. The calculated molecular weight is 94 kDa, however BICD2 has been shown as a ~100 kDa band in western blots. (Daniele, T., et al. (2011). Traffic. 12(7):902-911.) An uncharacterized band may appear at ~35 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected BICD2 in 10 µg/mL of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABN332 04053252831126