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ABC149 Anti-BST2 Antibody

Anti-BST2 is an antibody targeting the BST2 protein, validated for use in WB & IHC.

Anti-BST2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BST2 UniProt Number: Q10589
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ABC149
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC149
      ReplacesMABF201
      DescriptionAnti-BST2 Antibody
      Alternate Names
      • Bone marrow stromal antigen 2
      • BST-2
      • HM1.24 antigen
      • Tetherin
      Background InformationBST-2 also known as CD317 and Tetherin, bone marrow stromal antigen 2 (BST-2) is an interferon-inducible transmembrane protein that potently inhibits the release of nascent retrovirus particles. BST-2 is downregulated by the viral Vpu protein. BST-2 acts as a direct physical tether, which holds and links virions at the cell membrane. These tethered virons can remain on the cell surface or be internalized by endocytosis for degradation. BST-2 inhibits MMP2 and MMP15 activity, resulting in the attenuation of cellular proliferation and migration. BST-2 interaction with LILRA/ILT7 receptors in plasmacytoid dendritic cells negatively regulates IFN production in response to viral infection.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human bone marrow tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-BST2 is an antibody targeting the BST2 protein, validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected BST2 in human cardiac myocyte and human hepatocyte tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human BST2.
      Epitopeextracellular domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the extracellular domain of BST2
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BST2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~33 kDa observed. The calculated molecular weight of this protein is 20 kDa, but can be observed at ~25-35 kDa due to high glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human bone marrow tissue lysate.

      Western Blot Analysis: 1.0 µg/mL of this antibody detected BST2 in 10 µg of human bone marrow tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABC149 04053252832468