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MABN491 Anti-Brevican Antibody, clone N294A/6

Anti-Brevican, clone N294A/6 is an antibody targeting the Brevican protein, validated for use in WB & IHC.

Anti-Brevican Antibody, clone N294A/6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: Bcan, Behab UniProt Number: P55068
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MABN491
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN491
      DescriptionAnti-Brevican Antibody, clone N294A/6
      Alternate Names
      • Brevican core protein
      • Brain-enriched hyaluronan-binding protein
      • BEHAB
      • Brevican
      Background InformationBrevican core protein (BCAN), also known as Brain-enriched hyaluronan-binding protein (BEHAB) or Chondroitin sulfate proteoglycan 7 (CSPG7), may play a role in the terminally differentiating and the adult nervous system during postnatal development. It may stabilize interactions between hyaluronan (HA) and brain proteoglycans. Two isoforms exist, with isoform 1 (~99 kDa) being highly expressed from birth through 8 years of age and down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex; and isoform 2 (~72 kDa) being expressed at uniformly low levels throughout development.
      References
      Product Information
      FormatPurified
      Control
      • Rat brain tissue lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Brevican, clone N294A/6 is an antibody targeting the Brevican protein, validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: 2 µg/mL from a representative lot detected Brevican in 10 µg of human brain tissue lysate.

      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Brevican in rat midbrain, rat thalamus, and rat cerebellum tissues.

      Western Blot Analysis: A representative lot detected Brevican in rat brain tissue lysate and in WT, but not in Brevican knockout mouse brain tissue lysate.
      Biological Information
      ImmunogenRecombinant protein corresponding to rat Brevican.
      CloneN294A/6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Bcan
      • Behab
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~140 kDa observed. The calculated molecular weight of this protein is 96 kDa. A second isoform is known to exist at 69 kDa. This protein may be observed at a higher molecular weight due to glycosylation. A proteolyticaly cleaved fragment of Brevican may be observed at ~50 kDa in some tissue lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat brain tissue lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected Brevican in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABN491 04053252830822

      Documentation

      Anti-Brevican Antibody, clone N294A/6 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Brevican Antibody, clone N294A/6 Certificates of Analysis

      TitleLot Number
      Anti-Brevican, clone N294A/6 3082491
      Anti-Brevican, clone N294A/6 - 2499191 2499191
      Anti-Brevican, clone N294A/6 - 3239890 3239890
      Anti-Brevican, clone N294A/6 - 3462115 3462115
      Anti-Brevican, clone N294A/6 - 4081237 4081237
      Anti-Brevican, clone N294A/6 - 4167108 4167108
      Anti-Brevican, clone N294A/6 - Q2107392 Q2107392
      Anti-Brevican, clone N294A/6 -2523223 2523223
      Anti-Brevican, clone N294A/6 -2584443 2584443
      Anti-Brevican, clone N294A/6 -2821656 2821656
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