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CBL714 Anti-CD126 Antibody, clone B-R6

This Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.

Anti-CD126 Antibody, clone B-R6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: IL6R, MGC104991, IL-6R-alpha, IL6RA, CD126, gp80, IL-6R-1 UniProt Number: P08887
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CBL714
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, FC, IP, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL714
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD126 Antibody, clone B-R6
      Alternate Names
      • IL-6 Receptor, alpha Chain
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal was purified by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.4, containing 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesFlow cytometry: 1:50. Use 10 μL of this dilution to label 10e6 cells in 100 μL.

      Immunohistochemistry on frozen sections.

      Immunoprecipitation.

      ELISA

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenCHO cells transfected with a cDNA of the human IL-6 receptor.
      CloneB-R6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes both the soluble and membrane bound human IL-6 receptor. The antibody will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryInterleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
      Gene Symbol
      • IL6R
      • MGC104991
      • IL-6R-alpha
      • IL6RA
      • CD126
      • gp80
      • IL-6R-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08887 # Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
      SIZE: 468 amino acids; 51548 Da
      SUBUNIT: Hexamer of two molecules each of IL6, IL6R and IL6ST.
      SUBCELLULAR LOCATION: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
      DOMAIN: SwissProt: P08887 The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
      PTM: A short soluble form may also be released from the membrane by proteolysis.
      SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 subfamily. & Contains 1 fibronectin type-III domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2°-8°C for up to 12 months from date of receipt in undiluted aliquots.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      CBL714 04053252471681

      Documentation

      Anti-CD126 Antibody, clone B-R6 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CD126 Antibody, clone B-R6 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY - 2116652 2116652
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY - 2378748 2378748
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] - 3225736 3225736
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] - 3951346 3951346
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2550862 2550862
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2681167 2681167
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2696627 2696627
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2725221 2725221
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] -2767715 2767715
      MOUSE ANTI-HUMAN CD126 [IL-6Ralpha] MONOCLONAL ANTIBODY 3131823
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