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MABT883 Anti-CD315 Antibody, clone 17H1

This rat monoclonal Anti-CD315 antibody, clone 17H1, Cat. No. MABT883 is validated for use in Flow Cytometry and Immunohistochemistry for the detection of CD315.

Anti-CD315 Antibody, clone 17H1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: PTGFRN, CD9P1, EWIF, FPRP, KIAA1436 UniProt Number: Q9P2B2
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MABT883
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT883
      DescriptionAnti-CD315 Antibody, clone 17H1
      Alternate Names
      • CD9 partner 1
      • CD9P1
      • Glu-Trp-Ile EWI motif-containing protein F
      • nEWI-F
      • Prostaglandin F2-alpha receptor regulatory protein
      • Prostaglandin F2-alpha receptor-associated protein
      Background InformationProstaglandin F2 receptor negative regulator (UniProt: Q9P2B2; also known as CD9 partner 1, CD9P1; Glu-Trp-Ile EWI motif-containing protein F; nEWI-F; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein; CD315) is encoded by the PTGFRN (also known as CD9P1, EWIF, FPRP, KIAA1436) gene (Gene ID 5738 ) in human. CD315 inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific prostaglandin F2 alpha receptor, by decreasing the receptor number rather than the affinity constant. It is also reported to complex with 4-TM CD9 and CD81 and link them to the intracellular actin cytoskeleton. Its extracellular domain (ECD) contains six C2-type Ig-like domains (aa22-813) plus a Pro-Thr-Glu-Leu ER retention signal segment.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rat monoclonal Anti-CD315 antibody, clone 17H1, Cat. No. MABT883 is validated for use in Flow Cytometry and Immunohistochemistry for the detection of CD315.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesFlow Cytometry Analysis: 1:100 dilution of this antibody from a representative lot detected CD315 in one million U373 glioblastoma cells (Courtesy of Reinhard Zeidler, Helmholtz Zentrum Muenchen, Neuherberg, Germany in cooperation with Dr. A. Bankfalvi, Inst. für Pathologie Universitätsklinkum, Essen).

      Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected CD315 in Squamous cell carcinoma tissue (Courtesy of Reinhard Zeidler, Helmholtz Zentrum Muenchen, Neuherberg, Germany in cooperation with Dr. A. Bankfalvi, Inst. für Pathologie Universitätsklinkum, Essen).
      Biological Information
      ImmunogenMesothelioma cell-derived exosomes.
      Epitopeextracellular domain
      Clone17H1
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone 17H1 detects CD315 in A549 cells by Flow cytometry.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PTGFRN
      • CD9P1
      • EWIF
      • FPRP
      • KIAA1436
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight98.55 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in A549 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected CD315 in one million A549 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABT883 04054839154348