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AB6031 Anti-Integrin alpha-11 Antibody

Anti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB.

Anti-Integrin alpha-11 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGA11 UniProt Number: Q9UKX5
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AB6031
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB6031
      DescriptionAnti-Integrin alpha-11 Antibody
      Alternate Names
      • Integrin alpha-11
      Background InformationIntegrin alpha-11 (ITGA11) belongs to a family of cell adhesion molecules, which consist of noncovalent associated alpha-beta heterodimers, and is shown to be overexpressed in the stroma of human non-small-cell lung carcinomas (hNSCLCs). Upon dimerization, this protein is thought to enhance tumorgenicity of hNSCLCs by interacting with matrix collagen and stromal fibroblasts. Progesterone is shown to increase the expression of ITGA11 through mid-gestation and decrease thereafter in Sprague-Dawley rats. It is further indicated that MAPK signaling is associated with the regulation of these integrins.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Non-boiled & non-B-ME HeLa cell lysate
      PresentationPurified rabbit polyclonal containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenLinear peptide corresponding to human Integrin alpha-11.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with Human.
      Predicted to react with Mouse and Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
      Gene Symbol
      • ITGA11
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen.

      SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.

      SUBCELLULAR LOCATION: Membrane. Note: Single-pass type I membrane protein.
      Molecular Weight~135 kDa observed.
      The high molecular weight band seen in a HeLa (non boiled) cell lysate is the integrin complex. The band at ~75-80 kDa is thought to be a denatured form of integrin.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Integrin alpha-11 in 10 µg of non-boiled & non-B-ME HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      AB6031 04053252684470

      Documentation

      Anti-Integrin alpha-11 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Integrin alpha-11 - 2090951 2090951
      Anti-Integrin alpha-11 - 2216897 2216897
      Anti-Integrin alpha-11 - 2271215 2271215
      Anti-Integrin alpha-11 - 3184777 3184777
      Anti-Integrin alpha-11 - NRG1886279 NRG1886279
      Anti-Integrin alpha-11 -2585917 2585917
      Anti-Integrin alpha-11 -2765137 2765137
      Anti-Integrin alpha-11 Polyclonal Antibody 3028085
      Anti-Integrin alpha-11 Polyclonal Antibody 2970633
      Anti-Integrin alpha-11 Polyclonal Antibody 3096919