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423500 Anti-Klotho Rabbit pAb

This Anti-Klotho Rabbit pAb is validated for use in ELISA, Immunoblotting for the detection of Klotho.

Anti-Klotho Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-KL

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423500
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Overview

Replacement Information

Key Specifications Table

Species ReactivityHostAntibody Type
MRbPolyclonal Antibody

Pricing & Availability

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423500-50UG
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      		 Glass bottle 50 μg
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      Description
      OverviewRecognizes the ~100 kDa Klotho protein.
      Catalogue Number423500
      Brand Family Calbiochem®
      SynonymsAnti-KL
      References
      ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
      Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.
      Product Information
      FormLiquid
      FormulationIn PBS, 0.1% BSA, pH 7.5.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Application NotesELISA (1:10,000-1:100,000)
      Immunoblotting (1-10 µg/ml, chemiluminescence)
      Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
      ImmunogenMouse
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      423500-50UG 04055977187304

      Documentation

      Anti-Klotho Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Klotho Rabbit pAb Certificates of Analysis

      TitleLot Number
      423500

      References

      Reference overview
      Kuro-o, M., et al. 1997. Nature 390, 45.
      Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2009 RFH
      SynonymsAnti-KL
      ApplicationELISA (1:10,000-1:100,000)
      Immunoblotting (1-10 µg/ml, chemiluminescence)
      DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~100 kDa Klotho protein.
      BackgroundInactivation mutation of the recently discovered klotho gene in mice causes a syndrome resembling aging. Homozygous mutant klotho (kl/kl) mice exhibit premature aging phenotypes such as osteoporosis, age related skin changes, ectopic calcification, atrophy of genital organs and thymus, atherosclerosis, emphysema, ataxia, and short life span. The kl gene encodes a membrane protein whose extracellular domain carries homology to β-glucosidases. There also exists a splice variant of kl mRNA that encodes a putative secreted protein in both human and mouse. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway.
      HostRabbit
      Immunogen speciesMouse
      Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
      IsotypeIgG
      Speciesmouse
      FormLiquid
      FormulationIn PBS, 0.1% BSA, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsVariables associated with assay conditions will dictate the optimal working dilution.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
      Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.