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ABE433 Anti-L3MBTL1 Antibody

Detect L3MBTL1 using this rabbit polyclonal antibody, Anti-L3MBTL1 Antibody validated for use in western blotting.

Anti-L3MBTL1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: L3MBTL1, KIAA0681, L3MBT, L3MBTL UniProt Number: Q9Y468
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ABE433
200 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE433
      DescriptionAnti-L3MBTL1 Antibody
      Alternate Names
      • Lethal(3)malignant brain tumor-like protein 1
      • H-l(3)mbt
      • H-l(3)mbt protein
      • L(3)mbt-like
      • L(3)mbt protein homolog
      • L3MBTL1
      Background InformationL3MBTL1, also known as H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog, or L3MBTL1, and encoded by the gene L3MBTL1 /KIAA0681/L3MBT/L3MBTL, is a "reader" polycomb (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins and works to monitor the repressive state of genes. L3MBTL1 acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b and histone H4 leading to condensed chromatin and repressed transcription. L3MBTL1 also recognizes several other non-histone transcription factors such as p53 mono-methylated and works to mediate their target gene’s expression too. L3MBTL1 is localized to the nucleus in resting cells; in mitotic cells it is strongly associated with condensed chromosomes. L3MBTL1 is widely expressed I normal cells with lowered expression is seen in many cancer cells.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect L3MBTL1 using this rabbit polyclonal antibody, Anti-L3MBTL1 Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminus of human L3MBTL1.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • L3MBTL1
      • KIAA0681
      • L3MBT
      • L3MBTL
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~100 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected L3MBTL1 in 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABE433 04053252939587