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MABS1290 Anti-LANCL2 Antibody, clone 392

Detect LANCL2 using this mouse monoclonal Anti-LANCL2 Antibody, clone 392, Cat. No. MABS1290. It is used in Immunocytochemistry and Western Blotting.

Anti-LANCL2 Antibody, clone 392 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: LANCL2, GPR69B, TASP UniProt Number: Q9NS86
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MABS1290
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1290
      DescriptionAnti-LANCL2 Antibody, clone 392
      Alternate Names
      • Testis-specific adriamycin sensitivity protein
      Background InformationLanC-like protein 2 (UniProt: Q9NS86; also known as Testis-specific adriamycin sensitivity protein) is encoded by the LANCL2 (also known as GPR69B, TASP) gene (Gene ID: 55915) in human. LANC2 is a member of the highly conserved and widely distributed lanthionine synthetase component C-like (LANCL) protein family. It is well expressed in brain and testis and is localized to the plasma membrane, juxta-nuclear vesicles, and the nucleus. The N-terminus of LANCL2 differs from the other LANCL proteins by an N-terminal extension of 17 amino acid residues and an insertion of 19 residues. LANCL2 contains 15 cysteine residues, three of which are conserved in all human LANCL proteins and 8 are conserved between LANCL2 and LANCL1. LANCL2 displays about 75% amino acid homology with LANCL1 protein. LANCL2 contains a phosphatidylinositol phosphate (PIP) binding site at the N-terminus and its myristoylation is essential for its membrane association. LANCL2 is essential for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Exogenous expression LANCL2 in a sarcoma cell line is shown to reduce the expression of ABCB1 (P-glycoprotein 1) and increase cellular sensitivity to adriamycin. (Ref.: Sturla, L et al. (2009). J. Biol. Chem. 284(41):28045-57; Ladlinger, C et al. (2006). Biochim Biophys Acta. 1758(11):1759-67).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect LANCL2 using this mouse monoclonal Anti-LANCL2 Antibody, clone 392, Cat. No. MABS1290. It is used in Immunocytochemistry and Western Blotting.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A representative lot detected LANCL2 in Immunocytochemistry applications (Fresia, C., et. al. (2016). Sci Rep. 6:26658).

      Western Blotting Analysis: A representative lot detected LANCL2 in Western Blotting applications (Vigliarolo, T., et. al. (2015). J Biol Chem. 290(21):13042-52; Vigliarolo, T., et. al. (2016). Int J Biochem Cell Biol. 75:99-103).
      Biological Information
      ImmunogenGST-tagged full length human recombinant LANCL2 protein.
      Epitopeunknown
      Clone392
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 392 detected LANCL2 overexpressed in HEK293 cells.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LANCL2
      • GPR69B
      • TASP
      Purification MethodProtein A purified
      UniProt Number
      Molecular Weight~50 kDa observed; 50.85 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in lysates from HEK293 cells overexpressing LANCL2.

      Western Blotting Analysis: 4 µg/mL of this antibody detected LANCL2 in 10 µg of cell lysate from HEK293 cells overexpressing LANCL2.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABS1290 04054839167515